Subject:  News report (from Austria) about molecules/cancer........
Date:     Wed, 11 Mar 1998 154723 -0600 (CST)
From:     "Roy L. Beavers" <rbeavers@llion.org>
To:       emfguru@hotmail.com
--------------------------------------------------

Hi everybody:

The following news item (from Reuters) suggests some interesting
possibilities as to how EMF may be a factor in the process described.

Remember, molecules (composed of atoms) are basically "bundles of
bio-electromagnetic energy."  Their atomic weight is determined by their
nuclei and their chemical activity is determined by their electrons......

Either or both of these are subject to the influence of electro-magnetic
radiation (EMR) or (EMF).  Particularly the electron activity, it has
been suggested, could be disrupted by EMF exposures.....  Thus disrupting
'chemical' activity.....

Cheerio.....

Roy Beavers (EMFguru)
rbeavers@llion.org..............http://www.feb.se/EMF-L/EMF-L.html
................................It is better to light a single candle ...
than to curse the darkness...............................................

     _________________________________________________________________
   
10:52 AM ET 03/11/98

Molecule holds new clues about how cancer spreads

        
         Release at 2 P.M. EST)
            By Patricia Reaney
            LONDON (Reuters) - It's called E-cadherin and Austrian
scientists said Wednesday that it may hold vital clues to how
cancer spreads.
            They believe the molecule, which keeps cells together, could
help to explain how cancer progresses from a harmless benign
tumor to a potentially deadly malignancy.
            In a study published in the scientific journal Nature,
Gerhard Christofori and researchers at the Research Institute of
Molecular Pathology in Vienna show that the loss of E-cadherin
in tumors not only leads to malignancy, it actually speeds up
the process.
            ``Essentially in all human carcinomas (cancers) E-cadherin
is lost or down regulated during the transition from benign
tumors to malignant invasive tumors that will eventually lead to
metastasis,'' Christofori said in a telephone interview.
            If scientists could determine a way to stop the loss of
E-cadherin, they could be on their way to controlling the
disease and preventing metastasis or hidden dissemination of
cancerous cells to other parts of the body.
            Using specially bred transgenic mice with cancerous cells in
the pancreas, the scientists discovered tumors were stopped in
the benign stage if E-cadherin was present, but became invasive
if the molecule was missing.
            ``When we interfere with E-cadherin mediated cell adhesion,
tumor progression is accelerated and tumor progression is much
earlier and faster to the malignant stage and metastasis,'' said
Christofori.
            Cancer begins when control signals in a normal cell go
wrong. Instead of dividing systematically, abnormal cells divide
uncontrollably and cluster together to form a tumor.
            Benign tumors are harmless but once they become cancerous
cells can escape from the primary tumor and spread to other
sites in the body where they can form secondary tumors or
metastasis.
            Christofori said E-cadherin is important in that transition
to invasive cancer but does not explain the entire story.
            ``These results are surprising because the mere loss of cell
adhesion is not expected to enable cells ... to invade
surrounding tissue. It is likely that the loss of
E-cadherin-mediated-cell adhesion may convey additional signals
to induce tumour-cell invasion,'' he said.
            The molecule is also not a good drug target because it would
be difficult to replace it in every cancerous cell.
         ^REUTERS@




Archive provided courtesy of WaveGuide, http://www.wave-guide.org
Reprinted with permission of Roy Beavers, http://www.feb.se/EMF-L/EMF-L.html