Subject:  More support for the "suicide/EMF" connection (Phillips)..
Date:     Thu, 16 Mar 2000 140738 -0600 (CST)
From:     "Roy L. Beavers" 
To:       emfguru 
--------------------------------------------------


.........Following has been forwarded by Dr. Jerry Phillips
.....

He writes:  "[the following] Fits with the present discussion of
EMF exposure and suicide.  Your readers should be reminded of several
studies that appeared in the literature in the 80s and 90s also
providing a statistical association between 60 Hz EMF exposure and
increased suicide incidence."

http://www.ncbi.nim.nih.gov/htbin-post/Entrez/query?nid=
10700607&form=6&db=m&Dopt=b/  (Printed below)

Guru also takes note (in the experiment reported below) that a
dose-response ("intensity dependent") was observed.....

For those of you who (again) have been asking about Moulder ... and the
criteria of acceptance or rejection he applies to research ... in making
his statements that deny any existence of EMF bioeffects (at conditions of
exposure experienced in the "normal" work or home environment) ... the
following experiment is a good example of the kind of thing he routinely 
ignores.....  It has no no peer review, no replication.....  Just has
there has not been in the "suicide research" (of Savitz et al) reported
earlier today......

That kind of "don't accept the evidence until **conclusively proved**"
science is, of course, the kind of "science" that protected the tobacco
industry for more than fifty years.....  Hundreds of research results
like the following went ignored.....  We will soon be saying the same
about EMF -- "hundreds" of such results are being ignored ... by an
"establishment" tobacco-science criterion that is designed to protect the
vested interests....

.....While the tobacco-science Moulders of the world ... continue to
broadcast that "there is no problem."

Clearly, the "establishment" criterion is protective of $$$$$$$ at the
expense of people.....!!!!  It is simply NOT the approach that should
be taken in matters of public health.....  We will ALWAYS end up in the
"fix" that we have on lead, asbestos. tobacco, etc.....
[......Please look again at guru's "Open Message to the Decision Makers
on Lookout Mountain" ... on the website......guru.....]

Cheerio.....  (Jerry has provided an interesting study below --
particularly for our scientists, who may have forgotten it.....)

Roy Beavers (EMFguru)
roy@emfguru.com

.....It is better to light a single candle than to curse the darkness.....
                    NEW!!! Website... http://emfguru.com
...................People are more important than profits.................
                            Missed opportunity...
          $$$$$ We could have changed the corrupted system!! $$$$$
                                  McCain !!

PubMed medline query

Magnetic field desensitizes 5-HT(1B) receptor in brain: pharmacological 
and functional studies.

Massot O, Grimaldi B, Bailly J, Kochanek M, Deschamps F, Lambrozo J, 
Fillion G,
Unite de Pharmacologie Neuro-Immuno-Endocrinienne, Institut Pasteur, 25-28 
rue du docteur Roux, Paris, France

It was previously suggested that exposure to magnetic fields (MFs) could
generate dysfunction of the CNS. The physiological manifestations
described lead us to postulate that these symptoms might be related to a
dysfunction of the serotonergic system and particularly of the 5-HT
(1B) receptors. Accordingly, MFs could modify the conformation of these
receptors altering their functional activities. In rat brain membrane
preparations, we showed that the affinity constant of 5-HT for 5-HT(1B)
receptors was modified under exposure to MFs since K(d) varied from
4.7+/-0.5 to 12+/-3 nM in control and exposed (2.5 mT) membranes,
respectively. 

This effect was intensity-dependent (the sigmoidal dose-response curve
was characterized by an EI(50) of 662+/-69 muT and a maximal increase of
321+/-13% of the control K(d)), reversible, temperature-dependent and
specific to the 5-HT(1B) receptors. Similar results have also been
obtained with the human 5-HT(1B) receptors. In parallel assays, the 
functional activity of 5-HT(1B) receptors was investigated. 

The capacity of a 5-HT(1B) agonist to inhibit the cAMP production was
reduced by 37% (53.7+/-3.5% to 33.7+/-4.1%) following exposure to MFs and
the cellular activity of the receptors (inhibition of the synaptosomal
release of 5-HT) also was markedly reduced (66.5+/-3.2% to 28.5+/-4.2%).
These results clearly show that in in vitro assays, MF specifically
interacts with 5-HT(1B) receptors, inducing structural changes of the
protein that result in a functional desensitization of the receptors. 
Thus, in vivo, exposure to MFs may lead to physiological changes,
particularly in the field of mood disorders where the 5-HT system is
strongly involved.





Archive provided courtesy of WaveGuide, http://www.wave-guide.org
Reprinted with permission of Roy Beavers, http://www.emfguru.com